(Albany, US) DelveInsight has launched a new report on Leber’s Hereditary Optic Neuropathy Market
DelveInsight’s “Leber’s Hereditary Optic Neuropathy (LHON) – Market Insights, Epidemiology, and Market Forecast-2030” report delivers an in-depth understanding of the Leber’s Hereditary Optic Neuropathy (LHON) , historical and forecasted epidemiology as well as the Leber’s Hereditary Optic Neuropathy (LHON) market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan. The Leber’s Hereditary Optic Neuropathy (LHON) market report provides current treatment practices, emerging drugs, Leber’s Hereditary Optic Neuropathy (LHON) market share of the individual therapies, current and forecasted Leber’s Hereditary Optic Neuropathy (LHON) market Size from 2017 to 2030 segmented by seven major markets. The Report also covers current Leber’s Hereditary Optic Neuropathy (LHON) treatment practice/algorithm, market drivers, market barriers and unmet medical needs to curate best of the opportunities and assesses the underlying potential of the market.
Leber’s hereditary optic neuropathy (LHON) is a distinct type of “inherited optic atrophies” or “hereditary optic neuropathies.” It refers to an optic nerve dysfunction due to point mutations in the mitochondrial DNA and is transmitted in non-mendelian pattern. The primary cell type lost in LHON is the retinal ganglion cell, which is highly susceptible to disrupted ATP production and oxidative stress. Inheritance of LHON follows the mitochondrial genetics, and it has a highly variable clinical phenotype, as other genetic and environmental factors also play a role. It is characterized by bilateral subacute loss of central vision due to focal degeneration of the retinal ganglion cell layer and optic nerve. LHON most commonly presents as painless loss of central vision in one eye, followed rapidly by loss of vision in the other eye within a few months. In some cases, both eyes will be affected from the onset. It can have both ophthalmologic and extra-ocular features. Ophthalmologic manifestations can further be subdivided into the acute phase and chronic phase.
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Leber’s Hereditary Optic Neuropathy Treatment
The mainstay of clinical treatment for Leber’s hereditary optic neuropathy (LHON) remains supportive rather than curative. The management of LHON patients includes low vision aids, occupational rehabilitation, and registration with local social services. Those with mitochondrial mutations should be advised to refrain from smoking and binge alcohol drinking. Furthermore, screening for extraocular manifestations should be carried out in the form of an electrocardiogram and complete neurological evaluation. Nutritional supplements: combinations of vitamins (e.g., B2, B3, B12, C, E, and folic acid) and other supplements such as alpha-lipoic acid, carnitine, creatine, L-arginine, and dichloroacetate have been tried to treat mitochondrial disorders, including LHON. However, analyses have shown little proof of efficacy with these interventions.
Leber’s Hereditary Optic Neuropathy Market
The treatment of mitochondrial disorders is still in its infancy, even though there is promising research underway. LHON contributes significantly to the burden of blindness amongst young adolescents. Therefore, it becomes essential to evaluate and correctly identify the underlying genetic make-up.
Identification and mapping of the genes will help in preventing transmission to the offspring from the affected maternal carries. It will not only help in a better understanding of the disease but also help in exploring and evaluating different treatment modalities. In addition, the newly emerging treatment modalities, such as gene therapy, stem cells, and others, are likely to be a ray of hope for the individuals with these mutations; however, long term studies are needed to evaluate their role in terms of efficacy, benefits and adverse effects.
Leber’s Hereditary Optic Neuropathy Report Scope
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Table of content
1. Key Insights
2. Executive Summary of Leber’s Hereditary Optic Neuropathy (LHON)
3. Competitive Intelligence Analysis for Leber’s Hereditary Optic Neuropathy (LHON)
4. Leber’s Hereditary Optic Neuropathy (LHON) : Market Overview at a Glance
5. Leber’s Hereditary Optic Neuropathy (LHON) : Disease Background and Overview
6. Patient Journey
7. Leber’s Hereditary Optic Neuropathy (LHON) Epidemiology and Patient Population
8. Treatment Algorithm, Current Treatment, and Medical Practices
9. Unmet Needs
10. Key Endpoints of Leber’s Hereditary Optic Neuropathy (LHON) Treatment
11. Marketed Products
12. Emerging Therapies
13. Leber’s Hereditary Optic Neuropathy (LHON) : Seven Major Market Analysis
14. Attribute analysis
15. 7MM: Market Outlook
16. Access and Reimbursement Overview of Leber’s Hereditary Optic Neuropathy (LHON)
17. KOL Views
18. Market Drivers
19. Market Barriers
20. Appendix
21. DelveInsight Capabilities
22. Disclaimer
23. About DelveInsight
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