DelveInsight’s, “Metastatic Castration-Resistant Prostate Cancer Pipeline Insight 2023” report provides comprehensive insights about 75+ companies and 75+ pipeline drugs in the Metastatic Castration-Resistant Prostate Cancer pipeline landscape. It covers the Metastatic Castration-Resistant Prostate Cancer pipeline drug profiles, including Metastatic Castration-Resistant Prostate Cancer clinical trials and nonclinical stage products. It also covers the Metastatic Castration-Resistant Prostate Cancer pipeline therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Key takeaways from the Metastatic Castration-Resistant Prostate Cancer Pipeline
Discover the recent breakthroughs and advances in metastatic castration-resistant prostate cancer drug treatment @ Metastatic Castration-Resistant Prostate Cancer Pipeline Outlook
Recent Developmental Activities in the Metastatic Castration-Resistant Prostate Cancer Treatment Landscape
Metastatic Castration Resistant Prostate Cancer Overview
Prostate cancer (PCa) is one of the most prevalent malignancies in the world and the third most common cause of male cancer-related death in the United States of America (USA). The majority of men with newly diagnosed PCa present with localized disease and undergo radical prostatectomy and/or radiological therapy, followed by androgen deprivation therapy (ADT). Depending on the grade of the cancer, a variable percentage of these patients experience progression to castration-resistant prostate cancer (CRPC) within 10 years. CRPC was previously named “hormone-refractory prostate cancer” and “androgen-independent prostate cancer”. However, because castration treatments including ADT were ineffective, these cancers still showed reliance upon hormones for androgen receptor (AR) activation.
Find out more about metastatic castration-resistant prostate cancer treatment and Medication @ Metastatic Castration-Resistant Prostate Cancer Treatment Landscape
Metastatic Castration Resistant Prostate cancer Emerging Drugs
SRF617: Surface Oncology
SRF617 is a fully human antibody designed to inhibit the enzymatic activity of CD39 in the tumor microenvironment, allowing for a dual mechanism of action to promote anti-tumor immunity via reduction of immunosuppressive adenosine in addition to increasing levels of immunostimulatory ATP. SRF617 has been granted Orphan Drug designation for the treatment of advanced pancreatic cancer by the FDA.
Rucaparib: Clovis Oncology
Rucaparib is an oral, small molecule inhibitor of PARP1, PARP2 and PARP3 being developed in multiple tumor types, including ovarian and metastatic castration-resistant prostate cancers, as monotherapy, and in combination with other anti-cancer agents. Exploratory studies in other tumor types are also underway.
HP518: Hinova Pharmaceuticals
HP518, a highly selective and orally bioavailable chimeric degrader targeting androgen receptor (AR) with the potential to overcome the drug resistance of prostate cancer due to some specific AR mutations. In discovery and preclinical studies, HP518 showed high degradation activity against wild type AR and some specific AR mutants that are resistant to enzalutamide, and excellent antitumor activity in xenograft mouse models. HP518 is highly selective for AR.
Metastatic Castration Resistant Prostate Cancer Therapeutic Assessment
There are approx. 75+ key companies which are developing the therapies Metastatic Castration Resistant Prostate cancer. The companies which have their Metastatic Castration Resistant Prostate cancer drug candidates in the most advanced stage, i.e phase III include Clovis Oncology.
Learn more about the novel and emerging metastatic castration-resistant prostate cancer therapies @ Metastatic Castration-Resistant Prostate Cancer Ongoing Clinical Trials Analysis
Scope of the Metastatic Castration-Resistant Prostate Cancer Pipeline Report
Table of Content
For further information on the metastatic castration-resistant prostate cancer pipeline drugs therapeutics, reach out to Metastatic Castration-Resistant Prostate Cancer Key Companies and Therapies
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